1. Kylo-04  :

      Kylo-04  :

      For chronic hepatitis B (CHB) treatment 

      Features of  Kylo-04:

        Interrupt  the replication cycle of the viruses

      —      Reduces the production of new virus particles in the circulation by degrading all RNA from the virus

      —      Enhanced therapeutic effect with NUC drugs

      —      Enhanced immunological response to HBV viruseswith Interferon 

        Reduce immune tolerance in the body

      —      Inhibit HBsAg

      —      Inhibit HBeAg

        Recovering immune response against HBV

      —      Enhance the antiviral function of RNAi in return

      ※ Functional cure

      —      Achieve HBsAg clearance and conversion

      —     Prevent further deterioration of the disease to cirrhosis and liver cancer

      —     Clear viral DNA from the blood and restore liver function

      Comparison the effectof Kylo-04 with the listed nucleoside (NUC) on HBV: 


      DNA

      HBsAg

      HBeAg

      HBcAg

      Polymerase

      cccDNA

      Drug resistance

      Kylo-04               

       

      ×

      NUC                

      ×

      ×

      × 

      ×

      × 

       

      Currently available anti-HBV drugs at home and abroad include Interferon and nucleos(t)ide, such as Lamivudine, Adefovir Dipivoxil, Entecavir, Tenofovir and Telbivudine. The above drugs can only alleviate the symptoms and temporarily inhibit the virus. The amount of virus will rebound if medication is stopped so that lifelong medication is required. There are currently no means or drugs to cure hepatitis B virus infection worldwide. Moreover, current treatments have led to resistant strains, and there are no drugs against drug-resistant strains or drugs that prevent transmission.


      Research Progress: